Figure 2. Magnetization transfer ratio (MTR) in ΔMTR lesions.

As in figure 1, light lines indicate timecourses in individual lesions while heavy lines show the model predictions. The shaded gray area indicates the acute period, 3 months before and after lesion formation; this period was not included in the model, but is shown in the figure to illustrate the full MTR timecourse. The results in MTR lesions were consistent with gadolinium lesions: no significant difference in MTR between glatiramer acetate (GA)– and interferon-β-1b (IFN-β-1b)–treated patients before lesions formed but significantly better subsequent recovery in GA-treated patients. Random intercepts calculated by the model have been subtracted from the individual timecourses in this figure.