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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: IEEE Trans Biomed Eng. 2016 Apr 4;63(10):2047–2055. doi: 10.1109/TBME.2016.2550045

Figure 3.

Figure 3

PC to PP Ca2+ waves can be observed due to gradients of vasopressin receptor recycling rate as well as IP3 synthesis rate independently. Simulation results for PC to PP Ca2+ waves obtained with a (A) linear PC to PP kr gradient (2 to 1/s) with a constant kIP3 value (0.8μM/s), and (b) linear PC to PP kIP3 gradient (0.9 to 0.7μM/s) with a constant kr value (1.5/s) for all hepatocytes. Hepatocytes were numbered from 1 to 15 starting at the hepatocyte closest to the PC region. Either case resulted in diminishing Ca2+ spike amplitude from the PC to PP region. (See Table S4 for all parameters values).