Table.

Improvement in risk classification for first-onset composite cardiovascular disease outcomes by addition of information about NT-proBNP concentration compared with that about HDL-C

	Non-cases	Cases	Overall
Coronary heart disease plus stroke
Conventional risk factors without HDL-C concentration*	Reference	Reference	Reference
plus HDL-C concentration	0·001 (−0·003 to 0·004); p=0·70	0·008 (−0·000 to 0·016); p=0·056	0·009 (−0·000 to 0·017); p=0·056
plus HDL-C and NT-proBNP concentration	0·029 (0·025 to 0·032); p<0·0001	−0·001 (−0·009 to 0·007); p=0·79	0·027 (0·019 to 0·036); p<0·0001
Coronary heart disease plus stroke plus heart failure
Conventional risk factors without HDL-C concentration*	Reference	Reference	Reference
plus HDL-C concentration	0·011 (0·008 to 0·015); p<0·0001	0·006 (−0·001 to 0·013); p=0·10	0·017 (0·009 to 0·025); p<0·0001
plus HDL-C and NT-proBNP concentration	0·036 (0·032 to 0·040); p<0·0001	−0·008 (−0·017 to 0·001); p=0·087	0·028 (0·019 to 0·038); p<0·0001

Data are categorical net reclassification improvement versus preceding model (95% CI); p value. We calculated categorical net reclassification improvement across predicted 10 year cardiovascular disease risk categories defined by the American College of Cardiology and American Heart Association 2013 guidelines.¹ Analyses involved 4672 outcomes for the composite outcome of coronary heart disease plus stroke (from 19 cohorts) and 4071 for the composite outcome of coronary heart disease plus stroke plus heart failure (from 16 cohorts). HDL-C=HDL cholesterol. NT-proBNP=N-terminal-pro-B-type natriuretic peptide.

^*The reference model included information about age, sex, smoking, systolic blood pressure, history of diabetes, and concentration of total cholesterol.