FIG. 3.

Virtual uptitration for different dosing regimens of TI with simulated meal test in one illustrative in-silico subject. Upper panels: insulin (left) and glucose (right) in response to at-meal administration of four different dosages, shown in different colors. Middle panels: insulin (left) and glucose (right) in response to postmeal dosing (green lines) compared to at-meal dosing (blue lines). Lower panels: insulin (left) and glucose (right) in response to split dosing (green lines) compared to at-meal dosing (blue lines). Two scenarios for the 30 U split dose are shown for illustration.