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Glucose profiles of 100 virtual patients after in-silico meal test treated with insulin lispro. Each patient received an individualized insulin dose selected by a titration rule to target a glucose value of 160 mg/dL 120 min after start of the meal using at-meal dosing (A) or dosing 15 min before start of the meal (B). A comparison of the mean glucose profiles for at-meal dosing (blue) and premeal dosing (red) is shown in (C).
