FIG. 5.

Glucose time courses obtained by simulating meal test in 100 virtual subjects receiving an individualized at-meal dose of TI selected by titration rule based on PPG₉₀ < 160 mg/dL condition (A), or an individualized at-meal dose of TI selected by titration rule based on PPG₁₅₀ < 160 mg/dL condition (B), or an individualized postmeal dose (Δt = 15 min) of TI selected by titration rule based on PPG₁₅₀ < 150 mg/dL condition (C), or an individualized split dose (Δt = 15 min) of TI selected by titration rule based on PPG₁₅₀ < 150 mg/dL condition (D). A comparison of the mean glucose profiles for at-meal targeting PPG₉₀ < 160 mg/dL (blue), for at-meal dosing targeting PPG₁₅₀ < 160 mg/dL (red), postmeal dosing targeting PPG₁₅₀ < 150 mg/dL (green), and split dosing targeting PPG₁₅₀ < 150 mg/dL (magenta) is shown in (E). PPG, postprandial glucose.