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. 2016 Sep 1;27(9):668–678. doi: 10.1089/hum.2016.016

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© Diego Leon-Rico, et al., 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Figure 5. — Correction of the LAD-I phenotype in ex vivo GT-treated CD18^HYP mice. (A) Air pouch-based inflammation model in ex vivo GT-treated primary CD18^HYP recipients and control mice treated either with TNFα (proinflammatory stimulus) or CMC (vehicle). Experiments were performed 4 months after transplantation. Neutrophil emigration ratio is calculated from the total cell number found within the pouch and the percentage of Gr1⁺ cells determined by flow cytometry. (B) Neutrophil migration to a lung inflammation model based on LPS intranasal administration. The donor neutrophil migration ratio is calculated from the percentage of Ly6G⁺ CD11c⁻ donor neutrophils found in the bronchoalveolar lavage and in peripheral blood. The significance of differences between groups is expressed as *p < 0.05 and **p < 0.01.