FIG. 3.

Whole epigenome methylation profile. (A) Comparative analysis of iKCL004 and iKCL011 methylome found that 35,550 (7%) of CpGs are differently methylated between the two lines. Nearly a half of them were hypermethylated (18,815 or 53%) and the other half was hypomethylated (16,737 or 47%). Nearly twice more hypomethylated sites (3,516 or 18%) were found in body than hypermethylated sites (1,924 or 9%). Both hyper- and hypomethylated CpG sites were predominantly distributed in islands, shores, and shelves, across all chromosomes. (B) Manhattan plot, color-coded by chromosomes.