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Mean Shannon entropy values of NGS-generated sequences and relationship with viral load. (A to C) Shannon entropy values for polymorphic sites inferred for NGS sequencing methods based on metagenomic libraries (A), target enrichment (B), and PCR preamplification (C). Viral loads are plotted on log scales. (D and E) Shannon entropy values at each codon position in the consensus sequences inferred by each sequencing method based on the whole genome (D) and the nonstructural regions (E).
