Primary rotavirus infection decreases the risk of subsequent rotavirus infection. We used a Cox regression to estimate the independent time-dependent impact of a primary symptomatic rotavirus infection on the risk of secondary symptomatic infection among infants in our cohort in the first 3 years of life. Maternal age at birth, male sex, maternal education, cumulative months of exclusive (Exc.) breastfeeding, monthly income, and maternal BMI at birth were included in the model as time-independent covariates. Hazard ratio estimates are plotted with 95% confidence intervals for each variable included in the survival model. * indicates the level of significance, with ** indicating a P value of <0.001 and ** a P value of <0.0001.