Table 1.
Studies that reported testing for interactions, and/or comparing subgroups in an SCCS modeling context
| Study a | Exposure | Outcomes | Interaction Tested | Estimates/RIR/int. p-value reported |
|---|---|---|---|---|
| Wilson et al. [11] | 12 month MMR vaccination | ER visits + admissions | Sex | yes/yes/yes |
| Kwong et al. [26] | Influenza illness and influenza immunization | Guillain-Barré syndrome | Age, sex, month of vaccination | yes/no/yes |
| Benchimol et al. [13] | Influenza vaccination | ER visits + admissions + physician visits IBD flares | IBD versus healthy controls | yes/yes/yes |
| Wilson et al. [10] | 2, 4, 6 (DTaP) and 12 month (MMR) vaccination | ER visits + admissions | SES (Neighborhood income quintiles) | yes/yes/yes |
| Hawken et al. [23] | Acellular/whole cell pertussis vaccine | ER visits + admissions | Whole cell (1994–1996) versus acellular pertussis vaccine (1998–2000) | yes/yes/yes |
| Wilson et al. [12] | 2 month vaccination | ER visits + admissions | Preterm versus full term infants | yes/yes/yes |
| Wilson et al. [8] | 2, 4, 6 and 12 month vaccination | ER visits + admissions | Quintiles of birthweight | yes/yes/yes |
| Connolly-Anderson et al. [27] | Hemorrhagic fever with renal syndrome | Acute myocardial infarction and stroke | Sex | yes/no/yes |
| Langan et al. [28] | Herpes Zoster infection | Stroke | Antiviral Therapy | yes/no/yes |
| Dodd et al. [29] | H1N1 vaccination | Guillain-Barré syndrome | Age, sex, adjuvanted vs. non-adjuvanted vaccine, concomitant seasonal flu vaccine | yes/no/yes |
| Butt et al. [30] | Antihypertensives | Falls | Sex | yes/no/yes |
| Andrews et al. [31] | MMR vaccination | Thrombocytopenic purpura | Country | yes/no/yes |
| Tokars et al. [32] | H1N1 and seasonal influenza vaccination | Guillain-Barré syndrome | age, sex, vaccine type, received season flu vaccine, site | yes/no/yes |
| Pariente et al. [33] | Antipsychotic use | Myocardial infarction | Previous history of cardiovascular disease | no/no/nob |
| Warren-Gash et al. [34] | Influenza vaccination | Acute MI | Age group, sex, type of infarction, and history of vascular disease | yes/no/yes |
| Tse et al. [35] | Influenza vaccination | Febrile seizures | concomitant 13-valent pneumococcal conjugate vaccine (PCV13), age | yes/yes/yes |
| Gwini et al. [36] | Influenza vaccination | Acute myocardial infarction | Age, sex | yes/no/yes |
| Pattenden et al. [37] | Heat Exposure | Mortality | Ozone levels | yes/yes/yes |
| Andrews et al. [38] | Acellular pertussis/whole cell pertussis vaccine | Convulsions, | Whole cell period vs. acellular period | yes/yes/yes |
| Douglas et al. [39] | Thiazolidinediones | Fractures | Rosiglitazone versus pioglitazone | yes/no/yes |
| Miller et al. [40] | MMR | Convulsions and aseptic meningitis | Vaccine Manufacturer, Concomitant MCC vaccination vs. separate | yes/no/yes |
| Game et al. [41] | Initiation of dialysis | Foot ulceration | Haemodialysis vs. ambulatory peritoneal dialysis | no/no/noa |
| Miller et al. [42] | MMR vaccination | Gait Disturbance | doses of thimerisol containing vaccines by 4 months, \ mercury exposure intensity by 6 months | yes/no/yes |
| Sardinas et al. [43] | Oral polio vaccine | Intussusception | age | no/no/yes |
aStudies reported above the gray dividing bar are studies published by the authors and their collaboratorsbReported that interaction was tested and did not reach statistical significance