Table 2.
Multivariate associations of COMT single nucleotide polymorphisms with cognitive test z scores
| SNP | Allele | N | DSF | DSB | TMT-B | BTA | VF | HVLT-L | HVLT-D | HVLT-DI |
|---|---|---|---|---|---|---|---|---|---|---|
| rs4818 | CC (ref) | 31 | ||||||||
| CG | 74 | 1.97 (0.86) b | ||||||||
| GG | 45 | −0.59(0.31)a | ||||||||
| rs9332377 | AA.AG (ref) | 54 | ||||||||
| GG | 96 | −0.60 (0.31) b | −0.79 (0.39) b | −0.87 (0.33) c | −0.53 (0.31)aΔ | |||||
| rs165656 | CC | 29 | ||||||||
| CG | 72 | −1.34 (0.81)a | ||||||||
| GG | 49 | |||||||||
| rs5746847 | AA (ref) | 22 | ||||||||
| AG | 66 | 1.17 (0.49) b | ||||||||
| GG | 62 | 1.51 (0.66) b | 0.87 (0.46)a | |||||||
| rs165815 | AA (ref) | 101 | ||||||||
| AG.GG | 49 | −0.84 (0.32) c | −0.68 (0.31) b | |||||||
| rs4680 | AA (ref) | 27 | ||||||||
| AG | 73 | |||||||||
| GG | 50 | −2.05 (0.90) b | ||||||||
| rs5993883 | AA (ref) | 26 | ||||||||
| AC | 70 | −0.77 (0.46)a | −0.96 (0.54)a | −0.84 (0.46)a | ||||||
| CC | 54 | −1.22 (0.59) b | −0.71 (0.39)a | −1.05 (0.59)a | ||||||
| rs1800706 | AA (ref) | 18 | ||||||||
| AG | 66 | |||||||||
| GG | 66 | 0.77 (0.46)a | ||||||||
| rs4646312 | AA (ref) | 46 | ||||||||
| AG | 74 | −3.03 (1.44) b | ||||||||
| GG | 30 | |||||||||
| rs740603 | AA (ref) | 28 | ||||||||
| AG | 68 | 0.84 (0.41) b | 0.76 (0.40)a | |||||||
| GG | 53 | −1.19 (0.61) b | ||||||||
| rs165774 | AA.AG (ref) | 68 | ||||||||
| GG | 82 | −0.77 (0.26) c | 0.55 (0.32)a | 0.54 (0.31) | ||||||
| rs6269 | AA (ref) | 42 | ||||||||
| AG.GG | 108 | 2.16 (0.81) c | 1.06 (0.63)a | |||||||
| rs4646316 | C (ref) | 82 | ||||||||
| CT.T | 68 | −0.61 (0.32)a | −0.69 (0.31) b |
Beta and standard error values for 13 COMT single nucleotide polymorphisms (SNPs) retained in the multivariate regression models, controlling for age, education, treatment with RT±chemotherapy, time since treatment, and tumor location.
Blank cells indicate that the SNP was not associated with the given cognitive test. Only SNPs and cognitive tests showing significant or noteworthy albeit non-significant associations are included.
Underlined SNPs have NOT been reported previously in association with cognition.
a P< 0.10; b P ≤ 0.05; c P< 0.01.
Abbreviations: A, Adenine; C, Cytosine; G, Guanine; T, Thymine; BTA, Brief Test of Attention; DSB, Digit Span Backward; DSF, Digit Span Forward; HVLT-DI, Hopkins Verbal Learning Test-Discrimination Index; HVLT- L, Hopkins Verbal Learning Test-Learning; TMT-B, Trail Making Test, Part B; VF, Verbal Fluency Test.