Table 3.
Multivariate associations of brain-derived neurotrophic factor single nucleotide polymorphisms with cognitive test z scores
| SNP | Allele | N | DSB | TMT-B | BTA | HVLT-L | HVLT-D | HVLT-DI |
|---|---|---|---|---|---|---|---|---|
| rs10767664 | AA (ref) | 91 | ||||||
| AT.TT | 57 | −1.24 (0.73)a | −1.46 (0.68) b | |||||
| rs10835210 | AA (ref) | 37 | ||||||
| AC | 57 | |||||||
| CC | 56 | −1.03 (0.54)a | −0.74 (0.43)a | −1.36 (0.69) b | −1.52 (0.74) b | |||
| rs11030101 | AA (ref) | 52 | ||||||
| AT | 59 | |||||||
| TT | 39 | −1.59 (0.87)a | ||||||
| rs11030104 | AA (ref) | 93 | ||||||
| AG.GG | 57 | 0.96 (0.54)a | 1.98 (0.78) b | 1.28 (0.68)a | ||||
| rs11030107 | AA (ref) | 98 | ||||||
| AG.GG | 52 | −0.50 (0.31)a | ||||||
| rs2030324 | AA (ref) | 46 | ||||||
| AG | 62 | −1.74 (0.64) c | −1.15 (0.49) b | −1.01 (0.52)a | ||||
| GG | 41 | |||||||
| rs7127507 | AA (ref) | 81 | ||||||
| AG.GG | 69 | 1.24 (0.72)a |
Beta and Standard Error values for 7 BDNF the single nucleotide polymorphisms (SNPs) retained in the multivariate regression models, controlling for age, education, treatment with RT ± chemotherapy, time since treatment, and tumor location.
Blank cells indicate that the SNP was not associated with the given cognitive test. Only SNPs and cognitive tests showing significant or noteworthy, albeit nonsignificant, associations are included.
Underlined SNPs have not been reported previously in association with cognition.
Abbreviations: A, Adenine; C, Cytosine; G, Guanine; T, Thymine; BTA, Brief Test of Attention; DSB, Digit Span Backward; HVLT-D, Hopkins Verbal Learning Test- Delay; HVLT-DI, Hopkins Verbal Learning Test- Discrimination Index; HVLT-L, Hopkins Verbal Learning Test-Learning; TMT-B, Trail Making Test, Part B.
a, P < .10; b, P ≤ .05; c, P < .01