Table 4.
Multivariate associations of DTNBP1 single nucleotide polymorphisms with cognitive test z scores
| SNP | Allele | N | DSF | BTA | HVLT-D | HVLT-DI |
|---|---|---|---|---|---|---|
| rs1047631 | AA (ref) | 115 | ||||
| AG.GG | 35 | 0.50 (0.28)a | ||||
| rs3829893 | AA.AG (ref) | 56 | ||||
| GG | 94 | −0.51 (0.29)a | ||||
| rs742106 | AA.AG (ref) | 80 | ||||
| GG | 70 | −0.55 (0.32)a | −0.64 (0.31) b | |||
| rs9476886 | AA.AG (ref) | 96 | ||||
| GG | 52 | 0.48(0.27)a | 0.53(0.29)a |
Beta and Standard Error values for 4 DTNBP1 single nucleotide polymorphisms (SNPs) retained in the multivariate regression models, controlling for age, education, treatment with RT ± chemotherapy, time since treatment, and tumor location.
Blank cells indicate that the SNP was not associated with the given cognitive test. Only cognitive tests and SNPs showing significant or noteworthy albeit non-significant associations are included.
Underlined SNPs have not been reported previously in association with cognition.
Abbreviations: A, Adenine; C, Cytosine; G, Guanine; T, Thymine; BTA, Brief Test of Attention; DSF, Digit Span Forward; HVLT- D, Hopkins Verbal Learning Test- Delay; HVLT-DI, Hopkins Verbal Learning Test- Discrimination Index.
a, P < .10; b, P ≤ .05.