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. 2016 Apr 25;18(10):1402–1412. doi: 10.1093/neuonc/now061

Fig. 1.

Fig. 1.

NKG2D ligands are differentially expressed in IDHmut gliomas. RNA-seq analysis of 1639 immune-related genes (GO category 0050776) was compared in IDHmut and wt diffuse lower grade gliomas using TCGA data. (A) Unsupervised hierarchical clustering of the resulting 62 differentially expressed genes clustered by expression values using Pearson correlation. (B) Gene expression analysis of other known NKG2DLs from the same cohort as Fig. 1A. ULBP1 and ULBP3 expression was significantly lower in IDHmut compared with wt samples. (C) Comparison of NKGD2L mean methylation values in low-grade glioma patients (130 IDHmut, 32 IDHwt) from TCGA. (*P < .05, ***P < .001).