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. 2016 May 10;18(10):1390–1401. doi: 10.1093/neuonc/now089

Fig. 1.

Fig. 1.

Lomustine alone or in combination with Toca 511 + 5-FC survival in F98 tumor-bearing Fischer rats. (A) Schematic representation of the schedule of drug administration and blood collections. (B) Kaplan–Meier survival analysis. Groups of male Fischer rats were implanted i.c. with F98 cells then dosed i.c. with vehicle control or i.c. with Toca 511. Lomustine was administered at day 10. PBS or 5-FC started at day 10. Four cycles of PBS or 5-FC treatment were given to rats and survival was examined out to 80 days. (C) Summary of the survival analysis. (D) Blood samples were collected 7, 12, and 69 (survivors) days after tumor cell inoculation. WBC, LYM, PLT, and NEU were determined. Dotted line represents LLN for age-matched rats (*P < .05, **P < .01; day 7 vs day 12). (E) Alkaline phosphatase (ALP), alanine aminotransferase (ALT), and total bilirubin (TBIL) were determined (*P < .05, **P < .01; groups vs Toca 511 + 5-FC).