Table 1.

Summary of studies of different genetic mouse models of autophagy and the effects on hepatic lipid accumulation.

Animal model	Genetic alteration	Effect on autophagy	Diet	Effect	Ref.
Atg7F/F-Alb-Cre mouse	Hepatocyte-specific Atg7 knockout	Decrease	Normal diet	Increased steatosis, hepatic TGs and cholesterol	[9]
Atg14 shRNA adenovirus-infected mouse	Atg14 hepatic knockout	Decrease	Normal diet	Increased hepatic TGs	[46]
Atg14 expressing adenovirus-infected mouse	Atg14 hepatic overexpression	Increase	High fat diet	Decreased hepatic TGs	[46]
Atg7 adenovirus-infected ob/ob mouse	Atg7 hepatic overexpression	Increase	Normal diet	Decreased steatosis and liver TGs	[48]
Tcfeb-LiKO mouse	Hepatocyte Tfeb knockout	Decrease	Starvation or high fat diet	Increased steatosis and hepatic TGs	[47]
HDAd-TFEB mouse	Adenoviral TFEB overexpression	Increase	High fat diet	Decreased hepatic TGs	[47]
FILKO mouse	FIP200 hepatocyte knockout	Decrease	Normal diet with or without starvation	Decreased liver TGs with starvation	[49]
Cre adenovirus-infected FIP200F/F mouse	FIP200 hepatocyte knockout	Decrease	High fat diet	Decreased liver TGs	[49]
Atg7Δhep mouse	Atg7 hepatocyte knockout	Decrease	High fat diet or starvation	Decreased steatosis	[50]

Abbreviations: Tcfeb-LiKO, Tcfeb liver-specific knockout; FILKO, liver-specific FIP200 knockout