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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Trends Endocrinol Metab. 2016 Jun 25;27(10):731–741. doi: 10.1016/j.tem.2016.06.002

Fig. 2. The Diverse Activators of PLCγ.

Fig. 2

Activators of PLCγ known to activate the UPR are in bold. * indicates the activating tyrosine kinase has not been identified. #Ecdysone acts with a GPCR to open the IP3R calcium channels, but activation of the UPR arms has not been investigated. Tyrosine kinases that activate PLCγ are expected to activate the anticipatory UPR pathway. Peptide hormone receptors that are membrane tyrosine kinases that activate PLCγ are shown on the left. Src kinase has also been shown to activate PLCγ. Several steroid hormones activate Src kinase and are likely activators of the anticipatory UPR pathway (center). Immunoreceptors, shown on the bottom, working through GPCRs and Src family kinases are not mitogenic hormones and instead activate the UPR to antcipate the increased protein folding load that accompanies antibody production.