Table 2. Top 22 imputed meta-analysis SNPs for VWFpp.

Genome-wide significant (p-value < 5.0E-8) SNPs in GABC (EMMAX) + TSS (Plink) meta-analysis and individual cohorts, sorted by genomic location, with respect to their relationship to the nearest gene.

		*Meta-Analysis				GABC			TSS
SNP	Chr	Position†	SNP Allele	P-Value	Closest Gene	Allele Freq.	Beta (SE)	P-Value	Allele Freq.	Beta (SE)	P-Value
rs10251762	7	68335032	T	2.9E-08	AUTS2	0.078	0.034 (0.011)	2.9E-03	0.065	0.034 (0.0072)	2.4E-06
rs12531236	7	68336435	T	4.2E-08	AUTS2	0.081	0.034 (0.010)	1.6E-03	0.062	0.031 (0.0068)	6.3E-06
rs10246260	7	68338971	A	2.9E-08	AUTS2	0.078	0.034 (0.011)	2.9E-03	0.065	0.034 (0.0072)	2.4E-06
rs55800567	7	68340079	A	2.0E-08	AUTS2	0.079	0.035 (0.011)	2.0E-03	0.060	0.034 (0.0072)	2.4E-06
rs10252976	7	68343237	T	3.7E-08	AUTS2	0.92	−0.033 (0.011)	3.9E-03	0.93	−0.034 (0.0072)	2.4E-06
rs11977562	7	68349402	A	4.3E-08	AUTS2	0.92	−0.033 (0.011)	3.9E-03	0.94	−0.034 (0.0072)	2.8E-06
rs56835261	7	68356258	A	1.6E-08	AUTS2	0.92	−0.035 (0.011)	2.1E-03	0.93	−0.034 (0.0072)	1.9E-06
rs8176749	9	136131188	A	1.1E-13	ABO	0.070	0.052 (0.012)	2.0E-05	0.073	0.040 (0.0066)	8.5E-10
rs8176746	9	136131322	A	1.0E-13	ABO	0.070	0.052 (0.012)	2.0E-05	0.073	0.040 (0.0066)	8.3E-10
rs8176743	9	136131415	A	1.2E-13	ABO	0.070	0.052 (0.012)	2.0E-05	0.073	0.040 (0.0065)	9.5E-10
rs8176741	9	136131461	T	1.4E-13	ABO	0.070	0.052 (0.012)	2.0E-05	0.073	0.040 (0.0066)	1.1E-09
rs8176725	9	136132617	T	1.9E-09	ABO	0.093	0.042 (0.010)	5.7E-05	0.099	0.026 (0.0057)	4.5E-06
rs8176722	9	136132754	T	2.4E-09	ABO	0.093	0.042 (0.010)	7.0E-05	0.099	0.026 (0.0057)	4.8E-06
rs687289	9	136137106	T	6.4E-10	ABO	0.36	0.023 (0.0065)	2.7E-04	0.25	0.020 (0.0039)	4.7E-07
rs657152	9	136139265	T	1.7E-08	ABO	0.38	0.023 (0.0062)	1.7E-04	0.28	0.016 (0.0038)	1.5E-05

^*In the combined set of 934 individuals in the GABC and 2,304 individuals in the TSS cohort

^†Coordinates are in NCBI36/hg18

Chr: Chromosome

Beta values based on log transformed, adjusted VWFpp values.

SE: Standard error