Table 5.

Comparison of effect size and direction of top meta-analysis SNPs for VWF and VWFpp

			VWF		VWFpp
SNP (Minor Allele)	Chr	Locus	Beta*	P value*	Beta	P value
rs687289(A)†	9	ABO	0.096	7.7E-138	0.019	1.3E-9
rs8176746(T)‡	9	ABO	0.11	1.2E-49	0.044	1.6E-13
rs1063856(C)§	12	VWF	0.031	6.7E-17	0.014	7.7E-6
rs56835261(A)	7	Intergenic	0.015	3.5E-2	0.035	8.5E-9

SNPs were selected for further analysis if they were the top SNPs defining a locus in the meta-analysis for VWF[3] or VWFpp levels.

^*Results from previous VWF analysis[3]

^†This SNP tags the common O allele of ABO

^‡This SNP tags the common B allele of ABO

^§This SNP encodes a non-synonymous VWF variant T789P in D’ domain