Table 1.
PB analysis of mice with a myeloid-restricted deletion of ADAR1
| Population | +/+ | Δ/+ | Δ/Δ | Δ/− | p value |
|---|---|---|---|---|---|
| WBC (× 103/µL) | 11.1 ± 2.1 | 11.1 ± 3.6 | 11.2 ± 1.3 | 14.2 ± 3.8 | 0.155 |
| RBC (× 10 6/ µL) | 8.0 ± 0.5 | 8.4 ± 1.0 | 9.3 ± 0.9 | 8.7 ± 1.0 | 0.646 |
| Hgb (g/dL) | 15.1 ± 0.8 | 15.2 ± 1.1 | 15.7 ± 1.6 | 15.3 ± 1.0 | 0.880 |
| Hct (%) | 45.0 ± 1.9 | 42.3 ± 4.3 | 44.7 ± 4.6 | 42.9 ± 2.6 | 0.767 |
| MCH (pg) | 18.9 ± 1.0 | 18.0 ± 0.9 | 16.9 ± 0.1 | 17.6 ± 1.2 | 0.501 |
| MCHC (g/dL) | 33.5 ± 1.3 | 36.0 ± 2.7 | 35.2 ± 0.6 | 35.6 ± 1.4 | 0.707 |
| Plt (× 103/µL) | 749.3 ± 289.3 | 1169.3 ± 634.6 | 1321.5 ± 193.8 | 1367.4 ± 587.8 | 0.571 |
| Gran (× 10 2/ µL) | 11.0 ± 5.4 | 12.4 ± 7.4 | 9.3 ± 8.8 | 12.1 ± 5.7 | 0.958 |
| N | 3 | 4 | 6 | 7 |
Genotypes were LysM-Cre Adar1+/+(+/+), LysM-Cre Adar1Δ/+(Δ/+), LysM-Cre Adar1Δ/Δ (Δ/Δ), and LysM-Cre Adar1Δ/− (Δ/−). Data are expressed as mean ± SD; the number (n) of animals is indicated. Statistical significance (p value) between Δ/− and Δ/+ was calculated by unpaired t test. Gran = Granulocytes; Hct = hematocrit; Hgb = hemoglobin; MCH = mean corpuscular hemoglobin; MCHC = MCH concentration; Plt = platelet; WBC = white blood cells.