TABLE 1.
Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) comparing characteristics of ovarian cancer cases and controls stratified by menopausal status, the African American Cancer Epidemiology Study (AACES), 2010–2016.
| Pre-menopausal | Post-menopausal | All Women | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases n=175 n (%) |
Controls n=224 n (%) |
OR | 95% CI | Cases n=466 n (%) |
Controls n=528 n (%) |
OR | 95% CI | Cases n=641 n (%) |
Controls n=752 n (%) |
OR | 95% CI | |
| Age | ||||||||||||
| 20 – 29 | 7 (4.0) | 22 (9.8) | 1 (0.2) | 1 (0.2) | 8(1.3) | 23 (3.1) | ||||||
| 30 – 39 | 27 (15.4) | 55 (24.6) | 1 (0.2) | 2 (0.4) | 28(4.4) | 57 (7.6) | ||||||
| 40 – 49 | 90 (51.4) | 99 (44.2) | 20 (4.3) | 22 (4.2) | 110 (17.2) | 121 (16.1) | ||||||
| 50 – 59 | 48 (27.4) | 46 (20.5) | 165 (35.4) | 235 (44.5) | 213 (33.2) | 281 (37.4) | ||||||
| 60 – 69 | 3 (1.7) | 2 (0.9) | 177 (38.0) | 193 (36.6) | 180 (28.1) | 195 (25.9) | ||||||
| 70 – 79 | 102 (21.9) | 75 (14.2) | 102 (15.9) | 75 (10.0) | ||||||||
| Education | ||||||||||||
| ≤ High school graduate | 69 (39.4) | 69 (30.8) | 1.0 | Reference | 214 (45.9) | 211 (40.0) | 1.0 | Reference | 283 (44.2) | 280 (37.3) | 1.0 | |
| Some post-high school | 56 (32.0) | 84 (37.5) | 0.7 | (0.4–1.1) | 149 (32.0) | 182 (34.5) | 0.9 | (0.7–1.2) | 205 (32.0) | 266 (35.4) | 0.8 | (0.7–1.1) |
| ≥ College graduate | 50 (28.6) | 71 (31.7) | 0.8 | (0.4–1.3) | 103 (22.1) | 134 (25.4) | 0.8 | (0.06–1.1) | 153(23.9) | 205 (27.3) | 0.8 | (0.6–1.1) |
| Missing | 1 | 1 | ||||||||||
|
Family history of breast or ovarian cancer (1st degree) |
||||||||||||
| No | 128 (75.3) | 194 (89.0) | 1.0 | Reference | 333 (73.0) | 400 (78.4) | 1.0 | Reference | 461 (73.6) | 594 (81.6) | 1.0 | Reference |
| Yes | 42 (24.7) | 24 (11.0) | 2.4 | (1.3–4.2) | 123 (27.0) | 110 (21.6) | 1.4 | (1.0–1.9) | 165 (26.4) | 134 (18.4) | 1.6 | (1.2–2.1) |
| Missing | 5 | 6 | 10 | 18 | 15 | 24 | ||||||
| Age at menarche (years) | ||||||||||||
| <12 | 46 (26.3) | 57 (25.5) | 1.0 | Reference | 100 (21.5) | 143 (27.1) | 1.0 | Reference | 146 (22.8) | 200 (26.6) | 1.0 | Reference |
| 12 – 13 | 87 (49.7) | 113 (50.5) | 0.9 | (0.6–1.6) | 239 (51.3) | 249 (47.2) | 1.3 | (1.0–1.8) | 326 (50.9) | 362 (48.1) | 1.2 | (0.9–1.6) |
| >13 | 42 (24.0) | 54 (24.1) | 0.9 | (0.5–1.7) | 127 (27.3) | 136 (25.8) | 1.2 | (0.9–1.8) | 169(26.4) | 190 (25.3) | 1.1 | (0.8–1.5) |
| Age at menopause (yrs) | ||||||||||||
| <45 | 85 (19.0) | 110 (21.1) | 1.0 | Reference | ||||||||
| 45 – 49 | 108 (24.2) | 135 (25.9) | 1.0 | (0.7–1.5) | ||||||||
| 50 – 54 | 182 (40.7) | 203 (39.0) | 1.1 | (0.7–1.5) | ||||||||
| >54 | 72 (16.1) | 73 (14.0) | 1.1 | (0.7–1.7) | ||||||||
| Missing | 19 | 7 | ||||||||||
| Tubal Ligation | ||||||||||||
| No | 122 (69.7) | 148 (66.1) | 1.0 | Reference | 297 (64.0) | 301 (57.1) | 1.0 | Reference | 419 (65.6) | 449 (59.8) | 1.0 | Reference |
| Yes | 53 (30.3) | 76 (33.9) | 0.6 | (0.6–1.0) | 167 (36.0) | 226 (42.9) | 0.7 | (0.6–1.0) | 220 (34.4) | 302 (40.2) | 0.7 | (0.6–0.9) |
| Missing | 2 | 1 | 2 | 1 | ||||||||
|
Doctor diagnosed female infertility |
||||||||||||
| No | 127 (85.2) | 195 (92.4) | 1.0 | Reference | 396 (89.0) | 461 (92.2) | 1.0 | Reference | 523 (88.1) | 656 (92.3) | 1.0 | Reference |
| Yes | 22 (14.8) | 16 (7.6) | 2.5 | (1.2–5.3) | 49 (11.0) | 39 (7.8) | 1.6 | (1.0–2.6) | 71 (12.0) | 55 (7.7) | 1.9 | (1.3–2.8) |
| Missing | 26 | 13 | 21 | 28 | 47 | 41 | ||||||
|
Body mass index (kg/m2) 1 year prior to diagnosis/ interview |
0.25 | 0.11 | 0.11 | |||||||||
| <25 | 27 (15.6) | 46 (20.5) | 1.0 | Reference | 63 (13.6) | 95 (18.0) | 1.0 | Reference | 90 (14.1) | 141 (18.8) | 1.0 | Reference |
| 25 – <30 | 47 (27.2) | 48 (21.4) | 1.4 | (0.7–2.8) | 120 (25.9) | 150 (28.5) | 1.2 | (0.8–1.8) | 167 (26.2) | 198 (26.4) | 1.3 | (0.9–1.8) |
| 30 – <35 | 49 (28.3) | 54 (24.1) | 1.4 | (0.7–2.7) | 130 (28.0) | 135 (25.6) | 1.4 | (0.9–2.1) | 179 (28.1) | 189 (25.2) | 1.4 | (1.0–2.0) |
| ≥35 | 50 (28.9) | 76 (33.9) | 0.9 | (0.5–1.7) | 151 (32.5) | 147 (27.9) | 1.6 | (1.1–2.4) | 201 (31.6) | 223 (29.7) | 1.4 | (1.0–2.0) |
| Missing | 2 | 2 | 1 | 4 | 1 | |||||||
| Histology | ||||||||||||
| Serous | 84 (52.2) | 271 (62.9) | <0.0001† | 355(60.0) | ||||||||
| Endometrioid | 31 (19.3) | 44 (10.2) | 75(12.7) | |||||||||
| Mucinous | 17 (10.6) | 13 (3.0) | 30(5.1) | |||||||||
| Clear cell | 5 (3.1) | 8 (1.9) | 13(2.2) | |||||||||
| Other | 24 (14.9) | 95 (22.0) | 119(20.1) | |||||||||
| Missing | 14 | 35 | 48 | |||||||||
†
p-value comparing histology in pre-menopausal versus postmenopausal cases.