Table 4.

Univariate analysis for association of ROP findings from the first session image evaluation with incidence of treatment-requiring ROP

Findings from evaluation of images from the first session at 32–34 weeks PMA in either eye	# of infants	Treatment -requiring ROP (%)	OR (95% CI)	P-value
Posterior pole				<0.0001
Normal	601	37 (6.2%)	1.00
1 quadrant pre-plus	53	8 (15.1%)	2.71 (1.19 – 6.17)
2 quadrants pre-plus	39	9 (23.1%)	4.57 (2.02 – 10.3)
3 quadrant pre-plus	30	8 (26.7%)	5.54 (2.31 – 13.3)
4 quadrants pre-plus or any plus	33	16 (48.5%)	14.3 (6.71 – 30.7)
Unknown	15	7 (46.7%)	13.3 (4.59 – 38.8)
Stage of ROP				<0.0001
No	480	21 (4.4%)	1.00
Stage I or II	164	23 (14.0%)	3.57 (1.92 – 6.63)
Stage III	105	35 (33.3%)	10.9 (6.02 – 19.8)
Unknown	22	6 (27.3%)	8.20 (2.91 – 23.1)
Zone of ROP				<0.0001
No ROP	480	21 (4.4%)	1.00
II	208	29 (13.9%)	3.54 (1.97 – 6.37)
I	61	29 (47.5%)	19.8 (10.2 – 38.6)
Unknown	22	6 (27.3%)	8.20 (2.91 – 23.1)
Stage and zone of ROP				<0.0001
No ROP	480	21 (4.4%)	1.00
Stage 1–2, Zone II	136	12 (8.8%)	2.12 (1.01 – 4.42)
Stage 3, Zone II	72	17 (23.6%)	6.76 (3.36 – 13.6)
Stage 1–2, Zone I	28	11 (39.3%)	14.1 (5.89 – 33.9)
Stage 3, Zone I	33	18 (54.6%)	26.2 (11.6 – 59.1)
Unknown	22	6 (27.3%)	8.19 (2.91 – 23.1)
Any retinal hemorrhage				<0.0001
No	680	60 (8.8%)	1.00
Yes	91	25 (27.5%)	3.91 (2.30 – 6.66)
Dot hemorrhage				0.89
No	737	81 (11.0%)	1.00
Yes	34	4 (11.8%)	1.08 (0.37 – 3.14)
Blot hemorrhage				<0.0001
No	723	67 (9.3%)	1.00
Yes	48	18 (37.5%)	5.86 (3.11 – 11.1)
Flame hemorrhage				0.16
No	764	83 (10.9%)	1.00
Yes	7	2 (28.6%)	3.28 (0.63 – 17.2)
Pre-retinal hemorrhage				<0.0001
No	741	75 (10.1%)	1.00
Yes	30	10 (33.3%)	4.44 (2.00 – 9.84)