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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2016 Aug 14;309:15–23. doi: 10.1016/j.taap.2016.08.011

Figure 3.

Figure 3

Effects of TCDD on LPS- and PWM-induced IgM secretion in the SKW 6.4 and SKW-AHR+ cells. A. SKW 6.4 cells (1×106 cells/ml) activated with PWM. B. SKW-AHR+ cells activated with PWM. C. SKW 6.4 cells activated with LPS and D. SKW-AHR+ cells activated with LPS. SKW cells (1×106 cells/ml) were activated with LPS or PWM (150 μg/ml) and treated with 3, 10, 30 nM TCDD or vehicle (0.01% DMSO). Supernatants were harvested on day 5 post LPS activation and the amount of secreted IgM was measured by sandwich ELISA. The data are representative of three separate experiments with 4 experimental replicates per group. Statistical significance was determined using Dunnett's two-tailed t test; * represents values that are significantly different from naive at p < 0.05.