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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2016 Aug 14;309:15–23. doi: 10.1016/j.taap.2016.08.011

Figure 7.

Figure 7

Ability of the WT AhR and AhR variants to mediate TCDD-induced Cyp1B1 reporter gene activity. SKW cells were transiently transfected with Cyp1B1 reporter plasmid and treated with 30 nM TCDD or VH (0.01% DMSO) for 24h. Luciferase enzyme activity was determined as described in the Materials and Methods section. Results are expressed as a fold change relative to empty vector treatment, which was set to one. n=4 for each treatment; results are combined from 4 independent experiments. Significance was determined by a one-way ANOVA followed by a Dunnett's post hoc test. A “*” denotes significance compared with the corresponding vehicle (VH) control at p < 0.05.