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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2016 Aug 14;309:15–23. doi: 10.1016/j.taap.2016.08.011

Figure 9.

Figure 9

Effects of TCDD on the LPS-induced IgM secretion in SKW clones. SKW cells (1×105/ml) were activated with LPS (150 μg/ml) and treated with 0.3, 1, 3, 10, 30 and 100 nM TCDD or vehicle (0.01% DMSO). Supernatants were harvested on day 5 of culture and analyzed for IgM by sandwich ELISA. Data were normalized to VH control (100%) and presented as percentage of control. The data are combined from six separate experiments with four experimental replicates per group. Statistical significance was determined using Dunnett's two-tailed t test; * represents values that are significantly different from VH control at p < 0.05.