TABLE 4.
Generalized Estimating Equation (GEE) models testing differences in change in total FACT-B scores per 6 months after definitive surgical treatment over 2-year follow-up, by surgery type and receipt of chemotherapya
| Mean change (confidence limits) | P for trend | P for difference in trend | |
|---|---|---|---|
| Model with DCIS patients | |||
| Surgery type | 0.440 | ||
| BCS | 0.38 (0.01, 0.75) | 0.047 | |
| Mastectomy | 0.64 (0.09, 1.20) | 0.024 | |
| Chemotherapy | < 0.001 | ||
| No | 0.06 (−0.28, 0.40) | 0.720 | |
| Yes | 2.02 (1.35, 2.70) | < 0.001 | |
|
| |||
| Model without DCIS patients | |||
| Surgery type | 0.271 | ||
| BCS | 0.28 (−0.20, 0.76) | 0.256 | |
| Mastectomy | 0.80 (0.01, 1.59) | 0.046 | |
| Chemotherapy | < 0.001 | ||
| No | −0.18 (−0.66, 0.31) | 0.480 | |
| Yes | 1.77 (1.07, 2.47) | < 0.001 | |
FACT-B Functional Assessment of Cancer Therapy-Breast, BCS breast-conserving surgery
a
GEE models examining change in QOL by surgery type and chemotherapy were adjusted for covariates: age, race, education, marital status, BMI, social support, comorbidity, history of depression, surgical-side-effects severity, cancer stage, receipt of radiation therapy, and receipt of endocrine therapy