Table 2.

Brain regions showing significant interaction effect. The effect on brain connectivity was dependent on clinical status (control vs. case). Results in italics indicate trend effects of p < .1 and >.05.

				MNI coordinates
Seed Region	Brain region	vox	p value	z-max	z-max x (mm)	z-max y (mm)	z-max z (mm)
Right PAG	R Cerebellum VIIIac	54	.0479	3.66	14	−64	−56
	R Cerebellum VIIIbc	52	.0531	3.08	−18	−48	−60
	R laterobasal amygdalaa	28	.0383	3.1	28	−4	−18
	R SMA	157	.0284	3.72	12	−4	62
Left PAG	L laterobasal amygdalaa	21	.0454	2.87	−22	−4	−18
	R laterobasal amygdalaa	24	.0439	3.01	22	−4	−22
	R insulab/OFCd	95	.0361	3.73	30	20	−16
Right Amygdala	R medial OFCb/frontal poled	153	.0274	3.46	20	62	0
	hypothalamus	2	.0094	2.53	−8	−4	−4
	R insulad	166	.0087	3.26	40	8	−12
	L thalamusd (ventral lateral nucleusb)	164	.0107	3.19	−12	−6	4
	R SMA	106	.0692	3.39	4	18	46
	L anterior cingulateb,d	156	.0160	3.31	−2	36	2
	R anterior cingulateb,d	132	.0254	3.21	4	34	28

Brain regions labled according the (a)Juelich Histological Atlas, (b)Talaraich Atlas, the (c)Cerebellar Atlas in MNI space after normalization in FLIRT, and (d)Harvard-Oxford Cortical Structural Atlas.

R = right, L = left. PAG = periaqueductal gray, SMA = supplemental motor area, OFC = orbital frontal cortex.