Immunoglobulin trends for antigen-specific IgE, IgG4, IgA, IgA1, and IgA2 among groups. Responder status defined as passing a DBPCFC after at least 4 weeks off therapy at 22, 36 or 48 months. Graphs show logarithmic mean and SEM for each immunoglobulin measurement. Horizontal axis depicts time in months during the clinical trial.