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. 2016 Sep 26;3(5):ENEURO.0186-16.2016. doi: 10.1523/ENEURO.0186-16.2016

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Copyright © 2016 Goyer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Pharmacological block of muscarinic AChR hyperpolarized the resting membrane potential of SBC at physiological temperature. A, Resting membrane potential of n = 6 SBCs (thin gray lines) monitored for 20 min at 37°C. Black open circles and black lines: mean ± SEM measured at 30 s intervals; horizontal black bar, interval of tolterodine washin. B, Averaged RMP before [control (Ctrl), 0-4 min], during (Tol, 4-14min) and after [recovery (Rec), 14–20 min] washin of tolterodine. Gray markers connected by gray lines show individual SBCs; black open circle markers show mean ± SD of n = 6 SBCs. Black lines and asterisk show significant differences in post hoc testing, p < 0.05. C, R_m of n = 6 SBCs from the same measurements and same presentation as in A. D, Averaged R_m before, during, and after washin of tolterodine, with same presentation as in B.