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. 2016 Sep 26;3(5):ENEURO.0186-16.2016. doi: 10.1523/ENEURO.0186-16.2016

Figure 5.

Figure 5.

Cholinergic modulation increases SBC spike probability in vitro without a loss in temporal precision. A, Twenty-five repetitions of IVL stimuli were successively presented with a 3 s interval. Gray triangles, input spikes. B, Example response of one SBC to the IVL stimulus paradigm. Red dots, Failed AP; black dots, successful AP. C, Excerpts from IVL stimulus 18 under control conditions (Ci), under cholinergic modulation via carbachol (Carb; Cii), and with elevated RMP through Iinj (Ciii). Note the increase in spike probability. Markers, Red dots, failed AP; black dots, successful AP. Calibration: 20 mV and 50 ms. D, Increase in spike probability under cholinergic modulation. Di, Absolute change in spike probability for cholinergic modulation (Carb) and for RMP elevation through Iinj. Asterisks indicate significant difference (p < 0.01, paired t test). Dii, Mean relative change in spike probability for all cells in Di. Spike probability is increased twofold compared with control for both conditions. Asterisks indicate significant difference (p < 0.01, paired t test). E, Changes in vector strength under cholinergic modulation and RMP elevation. Ei, No significant change in absolute VS of SBC output for cholinergic modulation or RMP elevation was observed (p > 0.7, paired t test). Blue arrow denotes input-VS from the IVL stimuli. Eii, Only a slight, but not significant (p > 0.7, paired t test), increase in mean VS could be seen for both conditions.