Table 3.
TMS Characteristics and LMM Results
| TMS characteristics | |||
|---|---|---|---|
| Measurement | ASD (n = 9) | TDC (n = 9) | Statistic, p |
| Baseline MEP, mV | 1.9 (1.12) | 2.8 (1.7) | t16 = −1.29;p = 0.22 |
| RMT (Magstim Super Rapid2 Plus1) | 64.6 (15.8) | 63.2 (10.8) | t16 = 0.21; p = 0.84 |
| iTBS intensity | 45.3 (11.1) | 44.2 (7.6) | t16 = 0.25; p = 0.81 |
| LMM results and post-hoc analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fixed effect | DF | F-value | p | |||||||
| Baseline (subject) | 1,15 | 22.32 | <0.001a | |||||||
| Group | 1,15 | 0.44 | 0.52 | |||||||
| Time | 9,144 | 0.75 | 0.67 | |||||||
| Time × group | 9,144 | 2.05 | 0.04a | |||||||
| Post-hoc comparisons for Time × Group | ||||||||||
| Timepoint | 1 | 3 | 5 | 7 | 10 | 12.5 | 15 | 17.5 | 20 | 30 |
| df | 1, 68.85 | |||||||||
| F-value | 1.24 | 0.95 | 0.57 | 0.54 | 0.14 | 1.36 | 1.22 | 0.25 | 5.6 | 1.71 |
| p | 0.27 | 0.33 | 0.45 | 0.46 | 0.71 | 0.25 | 0.27 | 0.62 | 0.02a | 0.20 |
| Adjusted p | 0.019b | |||||||||
Timepoints are in minutes after TBS.
a
Statistical significance.
b
p After adjustment for multiple comparisons (Tukey–Kramer).
t68.85 = −2.37 (Kenward-Roger approximation for the degrees of freedom).
ASD, autism spectrum disorder; LMM, linear mixed model; MEP, motor-evoked potential amplitude; RMT, resting motor threshold as percentage of maximal stimulator output; TDC, typically developing children; TMS, transcranial magnetic stimulation.