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Identification of double-stranded RNA products with a slower migration by EM. Under the stimulation of TDRD3, Top3β-generated ds cRNA with a higher molecular weight was purified from the denaturing PAGE and observed by EM using a drop-spreading method. The contour length of each single circle is around 120 nm, indicating that multiple ds cRNAs are interlocked to form dimer or oligomer structures. (Scale bar, 50 nm.)
