Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 31;113(38):10720–10725. doi: 10.1073/pnas.1523230113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 5. — Proposed model for the role of DUS16 in miRNA biogenesis in Chlamydomonas. DUS16 associates, likely cotranscriptionally, with nascent pri-miRNAs. (Upper) In exonic pri-miRNA processing, DCL3-mediated cropping of a stem–loop generates pre-miRNA and cleavage fragments, which are quickly degraded in the wild type. Lack of processing results in exonic pri-miRNA accumulation in dus16-1. (Lower) In intronic pri-miRNA processing, because splicing appears to be unaffected by the DCL3-mediated processing of intronic pri- and/or pre-miRNA, the mature transcript is stably produced irrespective of the presence of functional DUS16. Generated pre-miRNAs may be exported to the cytoplasm and subjected to further processing.