Table S2.
Apoptotic array
| KLM1 | RH16 | KLM1 | RH16 | ||||||||||
| Symbol | Act D | RG7787 | Comb | Act D | RG7787 | Comb | Symbol | Act D | RG7787 | Comb | Act D | RG7787 | Comb |
| Abl | 1 | 1.1 | 0.9 | 0.8 | 1 | 1.1 | CRADD | 0.7 | 2.1 | 0.7 | 0.7 | 1.5 | 0.8 |
| Aif | 1.8 | 1.8 | 2.3 | 0.9 | 1 | 1.1 | cyt-c | 1.8 | 0.7 | 2.2 | 1.5 | 1.1 | 1 |
| akt1 | 1.3 | 1.1 | 1 | 0.8 | 0.8 | 0.8 | DAPK1 | 0.6 | 1.5 | 0.6 | 0.5 | 1.7 | 0.8 |
| apaf-1 | 1.3 | 0.6 | 0.7 | 1.8 | 1 | 1.9 | DFFA | 1.5 | 1 | 1.2 | 1.2 | 0.9 | 1.3 |
| Bad | 1.7 | 2.2 | 1.7 | 0.7 | 0.8 | 0.7 | Diablo | 1.8 | 2.9 | 2.8 | 1 | 1.1 | 1.4 |
| bag-1 | 1.1 | 0.6 | 0.7 | 1.2 | 0.8 | 1.1 | FADD | 1.5 | 2.1 | 1.1 | 0.8 | 1.2 | 1.1 |
| bag-3 | 0.9 | 1.2 | 1.4 | 1.3 | 1 | 1.7 | Fas | 1.1 | 2.4 | 1 | 5.9 | 0.1 | 6.1 |
| Bak | 1.2 | 1.6 | 0.9 | 1.3 | 0.7 | 1.4 | Fas-ligand | 1.1 | 0.7 | 1.6 | |||
| Bax | 1.5 | 1.3 | 1.6 | 1.4 | 0.7 | 1.7 | GADD45A | 4.1 | 63.1 | 30 | 4.5 | 4.1 | 21.2 |
| Bcl-10 | 2.2 | 4.3 | 3.2 | 2.3 | 1.9 | 3.9 | Harakiri | 1.2 | 1.1 | 0.9 | 2.4 | 3.1 | 2.2 |
| Bcl-2 | 2.2 | 0.6 | 0.4 | 0.7 | 0.9 | 0.3 | IGF1R | 0.7 | 2.6 | 0.8 | 0.7 | 0.9 | 0.8 |
| BCL2A1 | 3.4 | 7.4 | 21.6 | 2.1 | 19.2 | 22.6 | IL10 | 1.1 | 0.7 | 3.3 | |||
| Bcl-xL | 2.7 | 2.2 | 1.2 | 1.3 | 1 | 1.7 | Mcl-1 | 1.4 | 1.1 | 0.6 | 1.7 | 1.1 | 1.8 |
| Bcl-B | 1.8 | 0.7 | 0.5 | 0.4 | 0.3 | 0.8 | NAIP | 0.5 | 0.9 | 0.5 | 1.4 | 0.8 | 0.8 |
| Bim | 3.1 | 0.7 | 2.3 | 1.8 | 0.7 | 1.7 | NFkB | 1.6 | 8.5 | 3.2 | 1.1 | 3.2 | 2.1 |
| Bcl-w | 1.4 | 1.4 | 1.7 | 1.3 | 1.2 | 1.1 | NOD1 | 0.9 | 0.5 | 0.2 | 0.9 | 0.7 | 0.6 |
| Bfar | 1.4 | 1.6 | 1.1 | 0.7 | 0.8 | 0.8 | NOL3 | 1.9 | 0.8 | 1.4 | 2 | 0.5 | 1.2 |
| Bid | 1.2 | 0.9 | 1.4 | 0.9 | 0.8 | 1 | PYCARD | 1.1 | 0.6 | 0.6 | 1.3 | 0.6 | 1.2 |
| Bik | 1.8 | 6.1 | 3.6 | 2.5 | 1.1 | 4.1 | RIPK2 | 2.3 | 2.9 | 2.2 | 3.1 | 2.4 | 4.8 |
| Birc2 | 1.5 | 2.5 | 1.9 | 3.1 | 1.5 | 2.1 | TNF-α | 10 | 147.6 | 103.1 | 1.2 | 6.9 | 11.2 |
| CIAP | 4.7 | 46.3 | 13.2 | 8.6 | 5.7 | 9.8 | TNF-β | 1.2 | 7.5 | 13.4 | 4.8 | 2.9 | 3.5 |
| Birc5 | 2 | 1 | 3.2 | 0.2 | 0.6 | 0.3 | TNFR3 | 1.4 | 1.3 | 1.2 | 2.4 | 0.8 | 2.2 |
| Birc6 | 0.6 | 2.6 | 0.8 | 1.9 | 1.8 | 1.2 | TRAILR1 | 1.7 | 1.9 | 1.4 | 1.7 | 0.9 | 3.4 |
| Bnip-2 | 1.6 | 0.9 | 0.9 | 2.5 | 1.2 | 1.4 | TRAILR2 | 2.7 | 8.3 | 4.6 | 2 | 1 | 3.9 |
| Bnip-3 | 0.6 | 0.7 | 0.6 | 1.8 | 0.9 | 2.2 | TNFRSF11B | 2 | 0.5 | 0.6 | 0.6 | 4.1 | 2.2 |
| Bnip-3L | 1.3 | 0.4 | 1 | 3.7 | 1.2 | 2.2 | TNFR1 | 0.9 | 1.3 | 0.7 | 0.7 | 0.7 | 0.9 |
| Braf | 0.8 | 2 | 0.9 | 1.6 | 1.6 | 1.5 | TNFR2 | 10.5 | 15.5 | 8.1 | 0.5 | 0.6 | 0.4 |
| Caspase-1 | 0.7 | 0.3 | 0.4 | 15 | 1.3 | 13.5 | TNFRSF21 | 0.9 | 0.4 | 0.5 | 1.3 | 1.2 | 2 |
| Caspase-10 | 2.1 | 1.9 | 3 | 3.6 | 1.5 | 5.4 | TNFRSF25 | 1.1 | 0.5 | 0.2 | 2.6 | 0.6 | 1.4 |
| Caspase-14 | 1.1 | 0.7 | 0.5 | CD137 | 4.6 | 68.8 | 15.7 | 0.7 | 4.5 | 2.8 | |||
| Caspase-2 | 1.6 | 1 | 1.5 | 0.9 | 1.1 | 0.7 | TNFSF10 | 0.7 | 0.1 | 0.2 | 0.9 | 0.5 | 1 |
| Caspase-3 | 2.9 | 1.4 | 3.8 | 1.8 | 1.6 | 2.4 | TNFSF8 | 0.4 | 0.9 | 1 | |||
| Caspase-4 | 2 | 0.9 | 1.5 | 2.9 | 0.9 | 2.1 | TP53 | 2.4 | 5.6 | 8.8 | 1.5 | 1.1 | 1.6 |
| Caspase-5 | 2.8 | 0.7 | 5.6 | 2.8 | 1.3 | 3.5 | TP53BP2 | 1.6 | 5.8 | 3.7 | 1.6 | 1.7 | 1.8 |
| Caspase-6 | 1.3 | 0.6 | 1.1 | 1.1 | 0.8 | 1.1 | TP73 | 0.4 | 1.3 | 1.1 | 0.5 | 3.4 | 0.3 |
| Caspase-7 | 3.4 | 1.1 | 2.2 | 1.2 | 0.9 | 1.8 | TRADD | 1.2 | 0.4 | 0.5 | 0.9 | 1 | 1.8 |
| Caspase-8 | 1.7 | 1.1 | 1.1 | 2 | 0.9 | 1.3 | TRAP | 0.9 | 3.5 | 1.5 | 0.5 | 1.1 | 0.5 |
| Caspase-9 | 1.9 | 2.4 | 3.2 | 1 | 3.4 | 2.4 | TRAF3 | 0.9 | 3.8 | 1 | 0.7 | 1.1 | 0.8 |
| CD27 | 3.4 | 0.2 | 6.2 | 2.4 | 0.5 | 1.8 | XIAP | 1.1 | 1.4 | 0.6 | 2.7 | 1.7 | 2.1 |
| CD40 | 1.6 | 1.5 | 1.3 | ACTB | 1.4 | 1.8 | 1.8 | 1 | 1 | 0.9 | |||
| CD40LG | 1.1 | 0.7 | 1.1 | 1.2 | 0.5 | 0.6 | B2M | 2.3 | 1.7 | 2.4 | 1.7 | 1.2 | 1.5 |
| CD70 | 2.7 | 4.1 | 3.3 | 1.6 | 1 | 2.8 | GAPDH | 1.9 | 1.4 | 1.8 | 1.1 | 0.9 | 1.2 |
| Casper | 1.8 | 2.9 | 2.5 | 1.7 | 1.5 | 2 | HPRT1 | 1 | 1 | 1 | 0.5 | 1.1 | 0.6 |
| CIDEA | 1.1 | 1.1 | 1.2 | 2 | 2.6 | 0.6 | RPLP0 | 1.1 | 1 | 1.2 | 1.1 | 0.8 | 1.1 |
| CIDEB | 1.3 | 1.1 | 1.5 | 1.2 | 0.9 | 1 | |||||||
KLM1 cells were treated with Act D 10 ng/mL with or without 100 ng/mL RG7787 or RH16 cells were treated with Act D at 5 ng/mL and RG7787 (200 ng/mL) for 24 h. Total RNA was extracted, and reverse transcription and real-time PCR were performed with an apoptotic array kit (Qiagen). The numbers are generated using web-based data analysis (Qiagen) by setting the untreated control as 1 and using ACTB, B2M, GAPDH, HPRT1, and RPLP0 as internal controls.