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Mnb and ERK target different regions of Cic for phosphorylation. (A) Schematic diagram of the three Cic fragments (Cic1, Cic2, and Cic3) with locations of phosphorylation sites. (B) Mnb interacts with and phosphorylates only the amino-terminal Cic fragment, Cic1. (C) Phos-tag gel analysis of Cic1 phosphorylation. (C Bottom) Regular SDS/PAGE. (D) Mnb phosphorylates region Cic1, whereas activated ERK (ERKSem) phosphorylates region Cic3. (E) Summary of Cic binding and phosphorylation data.
