Fig. S3.

Heat map of clustering and clinical association for six differentially expressed miRNAs. Unsupervised hierarchical clustering performed on expression profiles for 16 serum samples reveals that, in general, samples of similar histology are clustered together. Interestingly, a subgroup of four samples identified to be indicative of VHR aggressive PCa cluster together using this molecular signature. Gleason scores are on the range of 9 (black) to 6 (light gray) to healthy (white). Tumor staging is on the range of T3 (black) to T1 (light gray) to healthy (white). Risk status scale is VHR, very high risk; HR, high risk; LR, low risk; or healthy. Patients were categorized based on the 2015 NCCN Guidelines for Prostate Cancer (Version 1.2015).