FIG. 1.

Study schema: A schematic representation of BM-hMSC (red) proliferation, osteogenic differentiation and further deposition of a mineralized (blue dots) ECM layer (yellow) on the surface of poly(propylene fumarate) (PPF) (blue) thin films under the influence of cytokines and other bioactive molecules. Finally, our goal of a tissue-engineered bone graft requires translation of our method for the production of bone substitute material, what we refer to as a “tissue-engineered bone graft” requires translating our protocol for ECM layer deposition on resorbable PPF thin films to 3D-printed PPF scaffolds with a Schoen gyroid pore geometry. 3D, three dimensional; BM-hMSC, bone marrow-derived human mesenchymal stem cell; ECM, extracellular matrix. Color images available online at www.liebertpub.com/tec