Table 2.

Physiological effects of continuous tamoxifen treatment in the female rat

Weight (g)
Treatment groups	0 DPI	21 DPI	35 DPI	Liver/brain weight ratio (35 DPI)
Sham PLB	246 ± 5.6	264.5 ± 7.3	279.5 ± 8.1	7.87 ± 0.32
n = 4				n = 5
Sham TAM	250 ± 6.2	259.5 ± 5.7	264 ± 7.8	7.91 ± 0.18
n = 4				n = 4
SCI PLB	221.5 ± 2.0	222.3 ± 3.6	239.5 ± 4.5	7.21 ± 0.41
t = 0 h				n = 10
n = 20
SCI TAM	221.6 ± 2.0	211.6 ± 3.3*	226 ± 2.7**	7.43 ± 0.67
t = 0 h				n = 7
n = 22

Physiological effects of continuous tamoxifen (TAM) treatment in the rat with SCI. To assess TAM appropriate release, animal weight was monitored weekly. TAM significantly reduced the animal weight at 21, 28, and 35 days post-injury (DPI) according to RM two-way analysis of variance Bonferroni post-test (F_(1,40) = 0.4540, treatment p = 0.0399, interaction p = 0.0015, DPI p < 0.001). Liver weight was normalized against the brain weight of each animal. Continous TAM administration for 21 days after SCI does not affect liver weight of treated rats when compared with placebo (PLB) (F_(3,22) = 0.4434, p = 0.7243).