Table 2. Distribution of offspring by double heterozygous-double heterozygous (PRL1^+/−/PRL2^+/−) mating at weaning indicates embryonic lethality of PRL1^−/−/PRL2^−/− double knockout mice and a survival disadvantage of PRL1^−/−/PRL2^+/− and PRL1^+/−/PRL2^−/− mice.

PRL1	+/+			+/−			−/−			n	χ2	p
PRL2	+/+	+/−	−/−	+/+	+/−	−/−	+/+	+/−	−/−
Observed	22	56	30	54	110	27	18	35	0	352	45.10	<0.001
Expected	22	44	22	44	88	44	22	44	22