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. 2016 Sep 10;8(9):248. doi: 10.3390/v8090248

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Human immunodeficiency virus type 1 (HIV-1) genome and Gag organization. (A) The Pr55^Gag protein. Major functions of the different domains are indicated; (B) The HIV-1 5′ untranslated region (UTR) contains the major packaging region SL1–SL4. The major Gag binding domain comprises nucleotides 227–237 in the NL43 strain [68]; (C) A region overlapping the Gag-Pol frameshift signal and (D) the Rev response element (RRE), might also be implicated in packaging. ZF: zinc finger; MA: matrix; CA: capsid; NC: nucleocapsid; p1: spacer domain SP2; p2: spacer domain SP1; TAR: Tat responsive element; Poly-A: polyadenylation signal, U5: unique 5′ region, PBS: primer binding site; SL: stem loop; DIS: dimerization initiation site; SD: splice donor; U3: unique 3′ region; R: repeat region; PR: protease; RT: reverse transcriptase; int: integrase; vif: viral infectivity factor; vpu: viral protein U; vpr: viral protein R; gp: glycoprotein; nef: negative factor.