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. 2016 Sep 21;7:12887. doi: 10.1038/ncomms12887

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Copyright © 2016, The Author(s)

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(a–d) Parafibromin (a), NICD (b) and β-catenin (c) immunohistochemistry of the mouse colon. H&E staining of the serially sectioned sample is shown in d. The right panels show higher-magnification images of crypt bases. Arrowheads indicate the positive nuclear staining of each antibody. Scale bars, 20 μm. (e,f) Immunohistochemical analysis of β-catenin and parafibromin expression (e) and β-catenin and NICD expression (f) in the bottom region of colonic crypts. Nuclei were stained in blue (DAPI). Arrowheads indicate the cells showing co-localization of parafibromin, β-catenin and NICD. Scale bars, 20 μm.