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. 2016 Sep 26;6:33853. doi: 10.1038/srep33853

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Copyright © 2016, The Author(s)

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(a) Hcn4 expression levels were significantly reduced in TG vs. WT (n = 16 per group; P < 0.05). (b) Heat map of whole mRNA transcriptome analysis of TBC1D10C TG vs. WT mice at the age of 20 weeks. (WT: n = 11, TG: n = 9; log2-fold change >0.25, P(adj) < 0.05). (SQ: template starting quantity.) (c) Examples of differentially expressed genes (Scn10a, Pdc1c, Sema3a) validated by quantitative real-time RT-PCR (WT: n = 11, TG: n = 9). (d) Scn10a expression was examined also in atrial myocardium. (e,f) TBC1D10C TG mice exhibited significantly prolonged action potential duration (APD), which was completely reversed by treatment with the specific Scn10a (Na_v1.8) inhibitor A-803467 (TG: n = 9 mice (27 cells); WT: n = 6 mice (21 cells); TG + A-803467: n = 4 mice (6 cells); WT + A-803467: n = 3 mice (6 cells); ***P < 0.0001; two-way RM-ANOVA and Bonferroni-post-test).