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. 2016 Sep 26;6:34036. doi: 10.1038/srep34036

Figure 2. Effects of PBA on cardiac hypertrophy induced by pressure overload in mice.

Figure 2

(A) Representative recording curves of blood pressure (BP). (B) Statistical results of systolic BP (SBP) recorded from the right carotid artery by invasive cannulation with a Millar Pressure Catheter in mice subjected to sham or TAC operation with or without PBA treatment (100 mg/kg/d, ip, for 6 weeks). Sham + Veh (n = 7); Sham + PBA (100 mg/kg/d, ip, n = 6); TAC (n = 9); TAC + PBA (100 mg/kg/d, ip, n = 12). (C) Representative images of whole hearts. (D) Whole view of heart cross sections stained with haematoxylin–eosin. (E) Cross-axis view of cardiomyocytes. (F) Long-axis view of cardiomyocytes. Scale = 20 μm in D and E. (G) The ratio of heart weight (HW) to body weight (BW). (H) Cardiomyocyte cross-sectional area. In (G) TAC group (n = 22), TAC + PBA group (n = 22), Sham group (n = 8), Sham + PBA group (n = 8). In (H) four mice in each group were selected and 400 cardiomyocytes per animal were chosen randomly. Data are expressed as mean ± SEM. *P < 0.05. NS, not significant; TAC, transverse aortic constriction; Veh, vehicle.