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. 2016 Sep 26;6:34036. doi: 10.1038/srep34036

Figure 7. The effects of different HDAC inhibitors on TAC-induced mortality.

Figure 7

(A) The chemical structures of the HDAC inhibitors, PBA, BS, TSA and VAL. (B) Kaplan–Meier analysis of the mortality rate of mice subjected to TAC surgery with or without HDAC inhibitor treatment for 6 weeks, including PBA (100 mg/kg/d, ip), BS (100 mg/kg/d, ip), TSA (0.6 mg/kg/d, ip) and VAL (0.71% in drinking water). (C) Western blots of H3 acetylation. (D) Representative image of whole hearts (left panel), and ratio of heart weight (HW) to body weight (BW) (right panel) of the TAC mice with or without low-dose PBA treatment (10 mg/kg/d, ip, for 6 weeks). Data are expressed as mean ± SEM. Sham + Veh (n = 4); Sham + PBA (10 mg/kg/d, ip, n = 4); TAC (n = 6); TAC + PBA (10 mg/kg/d, ip, n = 6). PBA (1), PBA 10 mg/kg/d; TAC, transverse aortic constriction.