Table 1. Descriptive statistics.
| All | Untreate | Treate | p-value | |
|---|---|---|---|---|
| N = 82 | N = 42 | N = 40 | ||
| Baseline | ||||
| Gender female n (%) | 53(0.65) | 27(0.64) | 26(0.65) | 1.0a |
| Age year | 40.6(9.6) | 42.9(9.2) | 38.2(9.5) | 0.029b |
| Disease duration | 7.5(7.7) | 6.9(9.3) | 8.1(5.5) | 0.5b |
| EDSS | 1.6(1.4) | 1.1(1.2) | 2.1(1.4) | <0.001b |
| EDSS median (range) | 2 (0–6) | 1 (0–5) | 2 (0–6) | <0.001c |
| Difference between two MRI month | 7.5(2.1) | 7.8(2.2) | 7.1(1.9) | 0.1b |
| T2-lesions n | 61(46.6) | 50.6(35.9) | 71.9(54) | 0.040b |
| T1-lesions n | 5.9(7.8) | 3.2(5.1) | 8.8(9.2) | 0.001b |
| GD-lesions n | 0.2(0.4) | 0.2(0.5) | 0.1(0.3) | 0.036b |
| Delta T2-lesions n/year | 3(5.7) | 3.9(6) | 2(5.4) | 0.1b |
| Delta T1-lesions n/year | 0.8(1.5) | 0.8(1.5) | 0.8(1.5) | 1.0b |
| NBV mm3 | 1,673,305(199,072) | 1,538,369(85,524) | 1,81,4987(185,529) | <0.001b |
| NWM mm3 | 740,634(71,743) | 737,318(45,178) | 744,115(92,304) | 0.7b |
| NGM mm3 | 932,671(179,778) | 801,051(53,533) | 1,070,872(160,836) | <0.001b |
| Change NBV %/year | −0.06(0.66) | −0.035(0.52) | −0.09(0.78) | 0.7b |
| Change NWM %/year | 0.15(0.57) | 0.021 (0.504) | 0.29(0.60) | <0.031b |
| Change NGM %/year | 0.02(0.75) | 0.006 (0.883) | 0.03(0.60) | 0.9b |
| aPBVC | 0.14(1.13) | 0.03(0.88) | 0.25(1.34) | 0.4b |
| Follow-Up | ||||
| Days of Follow-Up | 1,084(245) | 1,178(262) | 985(181) | <0.001b |
| EDSS | 1.93(1.27) | 1.48(1.07) | 2.41(1.29) | 0.001b |
| Delta EDSS | 0.32(0.97) | 0.37(0.92) | 0.26(1.03) | 0.6b |
| EDSS better n(%) | 7 (9) | 3 (7) | 4 (10) | 1.0a |
| EDSS stable n(%) | 55(67) | 28 (67) | 27 (68) | 1.0a |
| EDSS worse n(%) | 20 (24) | 11 (26) | 9 (23) | 1.0a |
| Treatment n(%) | 0.2a | |||
| De-escalation | 10(12) | Not applicable | 10(25) | |
| No change | 59(72) | 35(83) | 24(60) | |
| Escalation | 13(16) | 7(17) | 6(15) |
Notes.
Data presented as mean (sd) if not indicated otherwise.
TITLE
- Delta
- absolute differences
- Change
- relative difference per month
- EDSS
- Expanded Disability Status Scale
- T2-Lesion
- hyperintense on T2 weighted images
- T1-Lesion
- hypointense on T1 weighted images
- GD-lesions
- Contrast enhancing lesions
- NBV
- normalized brain volume
- NGV
- normalized grey matter volume
- NWM
- normalized white matter volume
Volumes only from SIENAX.
a
Differences between treated and untreated patients were tested with Chi-square test.
b
t-tests.
c
Mann–Whitney-U-test for ordinal data.