Table 2. Predefined classification algorithms.

Inflammation criteri	Atrophy criteria	High inflammation and low atrophy	High inflammation and low atrophy	Low inflammation and high atrophy	High inflammation and high atrophy	Chi-square	Anova
A	1	33	18	10	21	0.344	0.382
	2	24	27	16	15	0.214	0.521
	3	32	19	15	16	0.184	0.262
	4	24	27	15	16	0.877	0.477
B	1	35	18	8	21	0.304	0.806
	2	26	27	14	15	0.093	0.529
	3	34	19	13	16	0.195	0.469
	4	26	27	13	16	0.768	0.861
C	1	40	23	3	16	0.152	0.189
	2	29	34	11	8	0.089	0.614
	3	38	25	9	10	0.037*	0.261
	4	29	34	10	9	0.470	0.545
D	1	33	18	10	21	0.344	0.382
	2	24	27	16	15	0.214	0.521
	3	32	19	15	16	0.184	0.262
	4	24	27	15	16	0.877	0.477

Notes.

Predictive value of predefined classification algorithms allocating patients based on two MRI five to 14 months apart in high/low inflammatory and atrophy groups. ANOVA adjusted for treatment status. For details see method section.

^*p < 0.05.