. 2016 Sep 20;4:e2442. doi: 10.7717/peerj.2442

Table 4. Multivariate models and EDSS progression.

	Linear model
	R² = 0.29
Variables	Coeff	se	p-value
Intercept	0.723	0.149	<0.001
Treatment “yes”	0.433	0.202	0.035
Baseline EDSS	−0.370	0.071	<0.001
Change total grey matter volume	0.129	0.419	0.003
	Logit model
Area under the curve	0.82
Specificity %	72.6
Sensitivity %	85.0
NPV %	93.8
PPV %	50.0
Variables	OR	95% CI	p-value
Intercept	0.43	0.17–1.03	0.068
Treatment “yes”	2.96	0.77–13.54	0.132
Baseline EDSS	0.52	0.29–0.85	0.004
Change cortex volume	0.71	0.55–0.87	0.016

Notes.

Multivariate models investigating the predictive value of clinical and MRI measurements for EDSS progression. Details see methods and results.

Data presented as mean (sd) if not indicated otherwise.

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