Table 1.
Latency | Expressed EBV gene products | Normal B-cell stage | Associated disease |
III (growth) | EBER1-2, EBNA1-6, LMP1, LMP2A-B | Activated B lymphoblast | PT-DLBCL AIDS-related lymphoma Acute infectious mononucleosis |
II (default) | EBER 1-2, EBNA1, LMP1- 2A | B-cell undergoing the GC reaction | PT-DLBCL Classical Hodgkin lymphoma |
I | EBER 1-2 , EBNA1 | Memory B-cell | (PT-) Burkitt lymphoma (PT-) PBL |
EBER: Epstein-Barr virus-encoded RNA; EBNA: Epstein-Barr virus nuclear antigen; LMP: Latent membrane protein; PT-DLBCL: Post-transplant diffuse large B-cell lymphoma; PBL: Plasmablastic lymphoma; EBV: Epstein-Barr virus.