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. 2015 Nov 20;75(10):1763–1769. doi: 10.1136/annrheumdis-2015-207709

Figure 2.

Figure 2

Mean change in (A) GLOESS and the component scores for metacarpophalangeal joints 2–5, (B) GLOESS for the 22-paired joint set, (C) GLOESS for the reduced (nine-paired) joint set and (D) DAS28 (CRP) >24 weeks of treatment with abatacept plus methotrexate. Error bars represent 95% CIs. Data are for patients with baseline and at least one postbaseline assessment, with last observation carried forward. PDUS analyses were completed for 96 of the 104 patients, as patients from one site (n=8) were excluded due to compliance issues. (A) CI did not cross zero from week 1 for GLOESS: −0.7 (−1.2 to −0.1) or power Doppler: −0.9 (−1.5 to −0.3); CI did not cross zero from week 2 for synovial hyperplasia: −1.0 (−1.6 to −0.4); CI did not cross zero from week 4 for joint effusion: −0.8 (−1.4 to −0.3). (B) CI did not cross zero from week 1 −1.7 (−3.4 to −0.1). (C) CI did not cross zero from week 2 −1.5 (−2.4 to −0.6). (D) CI did not cross zero from week 1 −0.5 (−0.7 to −0.4). CMI, clinically meaningful improvement (ie, improvement from baseline in DAS28 score of ≥1.2); CRP, C reactive protein; DAS, disease activity score; GLOESS, Global OMERACT–EULAR (Outcome Measures in Rheumatology–European League Against Rheumatism) Synovitis Score; PDUS, power Doppler and greyscale ultrasound.